Ripretinib Versus Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor After Treatment With Imatinib (INTRIGUE): A Randomized, Open-Label, Phase III Trial

Author(s): Sebastian Bauer, MD1,2;Robin L. Jones, MD, MBBS3;Jean-Yves Blay, MD, PhD4;Hans Gelderblom, MD, PhD5;Suzanne George, MD6;Patrick Schöffski, MD7;Margaret von Mehren, MD8;John R. Zalcberg, MD, PhD9;Yoon-Koo Kang, MD, PhD10;Albiruni Abdul Razak, MRCP, MBBCh11;Jonathan Trent, MD, PhD12;Steven Attia, DO13;Axel Le Cesne, MD14;Ying Su, MD, PhD15;Julie Meade, MD15;Tao Wang, PhD15;Matthew L. Sherman, MD15;Rodrigo Ruiz-Soto, MD15;and Michael C. Heinrich, MD16,17
Source: DOI: 10.1200/JCO.22.00294 Journal of Clinical Oncology 40, no. 34 (December 01, 2022) 3918-3928.
Maem Hussein MD

Dr. Maen Hussein's Thoughts

Second line GIST, no difference in OS or PFS between sunitinib and ripretinib, but ripretinib is more tolerable.

Author Affiliations

1Department of Medical Oncology and Sarcoma Center, University Hospital Essen, Essen, Germany 2German Cancer Consortium (DKTK), Partner Site Essen, Germany 3Sarcoma Unit, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom 4Centre Léon Bérard, Lyon, France 5Leiden University Medical Center, Leiden, the Netherlands 6Dana-Farber Cancer Institute, Boston, MA 7Department of General Medical Oncology, Leuven Cancer Institute, KU Leuven, University Hospitals Leuven, Leuven, Belgium 8Fox Chase Cancer Center, Philadelphia, PA 9Monash University School of Public Health and Preventive Medicine and Department of Medical Oncology, Alfred Health, Melbourne, Victoria, Australia 10Asan Medical Center, University of Ulsan, Seoul, South Korea 11Toronto Sarcoma Program, Princess Margaret Cancer Center, Toronto, ON, Canada 12Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, FL 13Mayo Clinic, Jacksonville, FL 14Gustave Roussy, Villejuif, France 15Deciphera Pharmaceuticals, LLC, Waltham, MA 16Portland VA Health Care System, Portland, OR 17OHSU Knight Cancer Institute, Portland, OR

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